Publications

2017


Visualisation of an nsPEF induced calcium wave using the genetically encoded calcium indicator GCaMP in U87 human glioblastoma cells
L Carr, SM Bardet, D Arnaud-Cormos, P Leveque, RP O'Connor
BioelectrochemistryVolume 119: 68–75. DOI: 10.1016/j.bioelechem.2017.09.003

Infrared neural stimulation induces intracellular Ca2+ release mediated by phospholipase C
D Moreau, C Lefort, J Pas, SM Bardet, P Leveque, RP O'Connor
Journal of Biophotonics, DOI: 10.1002/jbio.201700020 (2017).

Nanosecond pulsed electric fields depolarize transmembrane potential via voltage-gated K+, Ca 2+ and TRPM8 channels in U87 glioblastoma cells
RC Burke, SM Bardet, L Carr, S Romanenko, D Arnaud-Cormos, P Leveque, RP O'Connor. 
Biochimica et Biophysica Acta (BBA)-Biomembranes, DOI: 10.1002/jbio.201700020 (2017).

Delivery devices for exposure of biological cells to nanosecond pulsed electric fields
M Soueid, MCF Dobbelaar, S Bentouati, SM Bardet, RP O’Connor, D Bessières, J Paillol, P Leveque, D Arnaud-Cormos.
Medical & Biological Engineering & Computing, 1-13 (2017).

Calcium-independent disruption of microtubule dynamics by nanosecond pulsed electric fields in U87 human glioblastoma cells. 
Carr L, Bardet, S, Burke, RC, Arnaud-Cormos, D, Leveque, P, O'Connor, RP. 

2016

Multiphoton imaging reveals that nanosecond pulsed electric fields collapse tumor and normal vascular perfusion in human glioblastoma xenografts.
Bardet, S, Carr, L, Soueid, M, Arnaud-Cormos, D, Leveque, P, O'Connor, RP.

Multicolor multiphoton microscopy based on a nanosecond supercontinuum laser source
Lefort, C, O'Connor, RP, Blanquet, V, Magnol, L, Kano, H, Tombelaine, V, Leveque, P, Couderc, V, Leproux, P.
Journal of Biophotonics, DOI: 10.1002/jbio.201500283, March 2016.

Studying the mechanism of neurostimulation with infrared laser light using GCaMP6s and Rhodamine B imaging
Moreau, D, Lefort, C, Bardet-Coste, S, O’Connor, RP.
Proceedings of SPIE, Volume 9690-58, Session 14, 7 pp. (conference paper/abstract)

Dosimetric characteristics of an EMF delivery system based on a real-time impedance measurement device
M Garcia-Fernandez, M, Percherancier, Y, Lagroye, I, O'Connor, RP, Veyret, B, Arnaud-Cormos, D, Leveque, P.
Biomedical Engineering, IEEE Transactions on , vol.PP, no.99, pp.1-1 
doi: 10.1109/TBME.2016.2527927,
 February 11, 2016.  

2015

Rhodamine B as an optical thermometer in cells focally exposed to infrared laser light or nanosecond pulsed electric fields.
Moreau, D, Lefort, C, Burke, RC, Leveque, P, O’Connor, RP.  
Biomedical Optics Express, 6(10), 4105-4117, 2015.  

Calcium-independent disruption of microtubule dynamics following nanosecond pulsed electric field exposure in U87 human glioblastoma cells 
Carr L, Bardet, S, Soueid, M, Arnaud-Cormos D, Leveque, P, O’Connor RP 
BioEM2015, June 15, 2015, Asilomar, California. (abstract)

In vivo multiphoton microscopy shows that a single 10 nanosecond pulsed electric field is sufficient to disrupt vasculature in xenografted human glioblastoma
Bardet S, Carr L, Soueid, M, Arnaud-Cormos D, Leveque P, O’Connor RP  
BioEM2015, June 15, 2015, Asilomar, California. (abstract)

Optical measurement of temperature by fluorescence in cells under infrared laser light illumination. 
Moreau D, Lefort C, Leveque P, O’Connor RP 
European Conferences on Biomedical Optics, June 23rd 2015, Munich, Germany. (conference paper/abstract)

Application of a voltage sensitive dye to study the effect of nanosecond pulsed electric fields (nsPEF) on membrane potential in human U87 glioblastoma cells
Burke R, Moreau D, Arnaud-Cormos D, Leveque, P, O’Connor RP  
BioEM2015, June 15, 2015, Asilomar, California. (abstract)

Optical measurement of temperature in biological cells under infrared laser light exposure (λ=800 nm)
Moreau D, Lefort C, Leveque P, O'Connor RP.
Proceedings of SPIE, Volume 9540, id. 95400F, 7 pp. (conference paper/abstract)

Optical Measurement of Temperature in Tissue Culture Surfaces under Infrared Laser Light Excitation at 800nm using a Fluorescent Dye
Lefort C, Moreau D, Leveque P, O'Connor RP
Photoptics, March 14 2015, Berlin, Germany. (conference paper/abstract)


2014

Sub-30-fs pulse compression and pulse shaping at the output of a 2-m-long optical fiber in the near-infrared range. 
Lefort, C, Kalashyan, M, Ducourthial, G, Mansuryan, T, O’Connor, RP, Louradour, F. 
Journal of the Optical Society of America B (JOSA B), 31(10), 2317-2324, 2014.

A modified TEM cell for real-time observation of biological cells exposed to microwaves. 
Soueid, M., Kohler, S., Bardet, SM, Carr, L, O’Connor, R.P., Leveque, P. Arnaud-Cormos, A. 
Progress in Electromagnetics Research (PIER), 149: 193-204, 2014.

Electrical measurements for nanosecond repetitive pulsed discharges. 
Arnaud-Cormos, D., Kohler, S, Bessieres, D., O'Connor, R.P., Paillol, J., Leveque, P. 
Transactions on Plasma Science, IEEE, 42(7): 1909-1916. 2014.

2013

Microchip laser-based optoelectronic system for kilovolt picosecond electromagnetic pulse generation. 
D. Arnaud-Cormos, RP. O'Connor, P. Leveque and V. Couderc. 
Photonics Technology Letters, IEEE, 25(23), pp.2308 -2310. 2013.

A versatile high-voltage nano- and sub-nanosecond pulse generator.
S. Kohler, V. Couderc, V., RP. O'Connor, D. Arnaud-Cormos, P. LEVEQUE
Transactions on Dielectrics and Electrical Insulation, IEEE, 20(4), 1201-1208, 2013.

Experimental microdosimetry techniques for biological cells exposed to nanosecond pulsed electric fields using microfluorimetry. 
Kohler, S., O'Connor, RP., Vu, T.T.,  Leveque, P., Arnaud-Cormos, D.
Microwave Transactions and Theory, IEEE, 61(5), 2015-2022, 2013.

2012

Electrooptic probe adapted for bioelectromagnetic experimental investigations.
P Jarrige, N Ticaud, S Kohler, RP O'Connor, L Duvillaret, G Gaborit, D Arnaud-Cormos, P Leveque
Instrumentation and Measurement, IEEE Transactions on 61 (7), 2051-2058, 2012.

Simultaneous high intensity ultrashort pulsed electric field and temperature measurements using a unique electro-optic probe.
S Kohler, P Jarrige, N Ticaud, RP O'Connor, L Duvillaret, G Gaborit, D Arnaud-Cormos, P Leveque
Microwave and Wireless Components Letters, IEEE 22 (3), 153-155, 2012.

Specific absorption rate assessment using simultaneous electric field and temperature measurements.
N Ticaud, S Kohler, P Jarrige, L Duvillaret, G Gaborit, RP O'Connor, D Arnaud-Cormos, P Leveque
Antennas and Wireless Propagation Letters, IEEE 11, 252-255, 2012

2011

Perception of sniff phase in mouse olfaction.
M Smear, R Shusterman, R O’Connor, T Bozza, D Rinberg
Nature 479 (7373), 397-400, 2011.

2010

Exposure to GSM RF fields does not affect calcium homeostasis in human endothelial cells, rat pheocromocytoma cells or rat hippocampal neurons
RP O'Connor, SD Madison, P Leveque, HL Roderick, MD Bootman
PLoS One 5 (7), e11828, 9, 2010.

Mitochondrial Ca2+ signalling and the effects of visible, radiofrequency and extremely low frequency electromagnetic fields. 
RP O'Connor 
PhD Dissertation, University of Cambridge, Cambridge, UK, 2010.

2009 and earlier

O’Connor, Shusterman, Smear, Bozza, Rinberg. Optogenetically targeted extracellular recordings reveal       heterogeneity in the responses of mitral cells connected to a single glomerulus.
Society for Neuroscience, Chicago, USA 2009. (Nanosymposium: New  Concepts and Technologies /abstract) .

Action potential detection by non-linear microscopy
L Sacconi, J Lotti, RP O’Connor, J Mapelli, D Gandolfi, E D'Angelo, FS Pavone
Proceedings of SPIE 7161, 71613F, 2009.

Optical recording of electrical activity in intact neuronal networks with random access second-harmonic generation microscopy
L Sacconi, J Mapelli, D Gandolfi, J Lotti, RP O'Connor, E D'Angelo, FS Pavone
Optics express 16 (19), 14910-14921, 2008.

Multidimensional custom-made non-linear microscope: from ex-vivo to in-vivo imaging
R Cicchi, L Sacconi, A Jasaitis, RP O’Connor, D Massi, S Sestini, V De, FS Pavone.
Applied Physics B: Lasers and Optics 92 (3), 359-365, 2008.

In vivo multi-photon nanosurgery on cortical neurons: Focusing on network organization
L Sacconi, RP O'Connor, A Jasaitis, A Masi, M Buffelli, FS Pavone
Proceedings of SPIE, the International Society for Optical Engineering, 2008.

In vivo multiphoton nanosurgery on cortical neurons
L Sacconi, RP O’Connor, A Jasaitis, A Masi, M Buffelli, FS Pavone
Journal of Biomedical Optics 12 (5), 050502-050503,2007.

Neutrophils from p40phox−/− mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing
CD Ellson, K Davidson, GJ Ferguson, R O'Connor, LR Stephens, PT Hawkins
The Journal of Experimental Medicine, 203 (8), 1927-1937, 2006.

Early publications from undergraduate and masters research...

Seizure onset times for rats receiving systemic lithium and pilocarpine: sources of variability
MA Persinger, LS Stewart, PM Richards, T Harrigan, RP O'Connor, YRJ Bureau
Pharmacology Biochemistry and Behavior 71 (1), 7-17 13, 2002.

Synergistic induction of severe hypothermia (poikilothermia) by limbic seizures, acepromazine and physical restraint: Role of noradrenergic α-1 receptors
MA Persinger, RP O'Connor, YRJ Bureau, GH Parker, O Peredery, M Zegil
Pharmacology Biochemistry and Behavior 70 (2), 341-352, 2001.

Geophysical variables and behavior: Days with sudden infant deaths and cardiac arrhyhtmias in adults share a factor with PC1 geomagnetic pulsations: Implications for pursuing mechanisms.
MA Persinger, RP O'Connor
Perceptual and Motor Skills 92 (3), 653-654, 2001.

Normal spatial memory following postseizure treatment with ketamine: selective damage attenuates memory deficits in brain-damaged rodents.
SA Santi, LL Cook, MA Persinger, RP O'Connor
International Journal of Neuroscience 107 (1-2), 63-76, 2001.

A linear relationship between postnatal geomagnetic activity and self-reports of epileptic seizures in young adults. 
MA Persinger, RP O'Connor
Perceptual and Motor Skills 89 (2), 368-370, 1999.

Geophysical variables and behavior: LXXXV. Sudden infant death, bands of geomagnetic activity, and PC1 (0.2-5 Hz) geomagnetic micropulsations
RP O'Connor, MA Persinger
Percept and Motor Skills 88 (2), 391-397, 1999.

Geophysical variables and behavior: LXXXH. A strong association between sudden infant death syndrome and increments of global geomagnetic activity--possible support for the melatonin hypothesis.
RP O'Connor, MA Persinger
Perceptual and Motor Skills 84 (2), 395-402, 1997.

Increases in Geomagnetic Activity are Associated with Increases in Thyroxine Levels in a Single Patient Implications for Melatonin Levels
RP O'Connor, MA Persinger
International Journal of Neuroscience 88 (3-4), 243-247, 1996.
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